New Report Recommends Near-Term Strategies for HPC Centers to Prepare for Quantum Integration 

Insider Brief

• Alice & Bob and Hyperion Research released a joint report projecting that early fault-tolerant quantum computing (eFTQC) will accelerate critical high-performance computing (HPC) applications within the next five years.
• The study estimates that up to 50% of workloads at top U.S. government HPC facilities could benefit from eFTQC, especially in fields such as materials science, quantum chemistry, and fusion energy.
• The report urges HPC centers to prepare now by co-designing hybrid workflows, developing software stacks, and training users to integrate quantum processors alongside CPUs and GPUs.
• Image: Photo by İsmail Enes Ayhan on Unsplash

PRESS RELEASE — Alice & Bob, a global leader in the race for fault-tolerant quantum computing, and Hyperion Research, the premier industry analysis and market intelligence firm for high performance computing (HPC), today announced the release of a joint report detailing how early fault-tolerant quantum computing (eFTQC) will accelerate solutions in critical HPC applications beyond classical supercomputing capabilities within the next five years. 

The study, “Seizing Quantum’s Edge: Why and How HPC Should Prepare for eFTQC,“ provides guidance on how HPC professionals can invest today in the design and integration of useful hybrid workflows for near-term applications. 

According to the report, up to 50% of current HPC workloads at top U.S. government research institutions like Los Alamos National Laboratory, the National Energy Research Scientific Computing Center and U.S. Department of Energy leadership computing facilities could benefit from eFTQC. 

“Quantum technologies are a pivotal opportunity for the HPC community, offering the potential to significantly accelerate a wide range of critical science and engineering applications in the near-term,” said Bob Sorensen, Senior Vice President and Chief Analyst for Quantum Computing at Hyperion Research. “However, these machines won’t be plug-and-play, so HPC centers should begin preparing for integration now, ensuring they can both influence system design and gain early operational expertise.”

The report describes how physical limits on transistor size and chip energy capacity have considerably slowed performance gains in classical HPC systems in the past 10 years. Meanwhile, the timeline to useful quantum applications has shortened, as evidenced by the 1000x reduction in the estimated resources required to run Shor’s algorithm. 

In the next 5 years, the report projects that quantum computers with 100 to 1,000 logical qubits and a logical error rate between 10^-6 and 10^-10 will significantly accelerate scientific computing applications starting with materials science and rapidly reaching quantum chemistry and fusion energy simulations. 

“HPC users will see benefits in accuracy, time-to-solution and computational cost as hybrid HPC-quantum workflows shift some computationally complex subproblems to quantum processors,” said Théau Peronnin, CEO of Alice & Bob. “HPC centers that want to lead have to co-design these hybrid workflows with users and vendors, shape efficient software and hardware infrastructure and deploy eFTQC prototypes to secure first-mover advantage.” 

The report describes how to integrate eFTQC, GPUs, and CPUs into an existing supercomputing center and includes recommendations for building application codes for HPC users, developing the hybrid software stack, and training the HPC user base for eFTQC adoption. 

To establish a quantum-ready workforce and infrastructure and maximize the benefits of quantum processing, the report recommends that HPC centers explore heterogeneous workloads by collaborating with quantum vendors today. 

“The HPC community has always been quick to adopt disruptive architectures – from vector processors to GPUs – and quantum computing is no exception,” said Juliette Peyronnet, US General Manager at Alice & Bob, who co-authored the report. “This work is a call to action for HPC centers to begin preparing for eFTQC integration now, so they are ready to harness the next major HPC accelerator.” 

Read the full report here: https://alice-bob.com/wp-content/uploads/2025/08/Seizing-Quantum-Edge-eFTQC-HPC-Report-Alice-Bob.pdf