AI–Quantum Research for Fault Detection Wins 2025 HPC Innovation Award

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Insider Brief

  • SiC Systems, ORCA Computing, Novo Nordisk, and DTU won the 2025 HPC Innovation Excellence Award for research combining AI and quantum computing to detect manufacturing faults.
  • The team created a quantum-enhanced AI system that builds high-resolution digital twins to identify minute defects in biomanufacturing processes.
  • The study shows that unsupervised AI, supported by quantum methods, can monitor complex industrial systems without prior fault data and deliver practical early-stage quantum computing value.

PRESS RELEASE — Breakthrough research has made clear how AI and quantum computing can be used to identify tiny, otherwise undetectable faults in manufacturing processes. This means they can be mitigated before they become expensive problems to fix.

The research, conducted by SiC Systems, Inc., ORCA Computing, Novo Nordisk, and the Technical University of Denmark has won the 2025 HPC Innovation Excellence Award, the world’s most prestigious High Performance Computing prize. Previous awardees have included NVIDIA, NASA, Argonne National Lab, and Microsoft.

The award-winning research utilized quantum computing to enhance traditional AI, enabling the team to create a high-resolution ‘digital twin’ of a biomanufacturing plant that accurately modeled normal operations in incredible detail. This allowed the AI to be able to detect minute defects in raw materials that can cost manufacturers millions of dollars in lost revenue. 

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The groundbreaking research shows that unsupervised AI, enhanced by quantum computing, can monitor complex systems without having any prior information about what faults look like. It also shows how quantum computers, even in their current early stages of maturity, can be put to practical use.

“Winning the HPC Innovation Excellence Award is a true honor. It’s a real validation of how much of a breakthrough our research is in showing how smarter monitoring can lead to more reliable manufacturing processes.

“We have shown that quantum computing is not an all-or-nothing future technology. It is already being pragmatically integrated to solve tangible problems today. By creating better synthetic data to overcome the scarcity of real-world failure examples, quantum-enhanced AI is sharpening the ‘senses’ of industrial monitoring systems.”

— said Dr. Christopher Savoie, Founder and CEO at SiC Systems

“This joint effort and the recognition is a testament to the value of cross-Atlantic collaboration between industry and academia to solve the world’s most pressing challenges.”

— said Dr. Richard Murray, Co-Founder and CEO at ORCA Computing

“This result, alongside the recent announcements from Google and Quantinuum, will be remembered as the moment we have stepped into the era of quantum advantage and we are incredibly proud to have backed the team that is making history.” 

— said Dr. Kris Kaczmarek, Investment Director at QDNL Participations

“This is a major achievement for us within the process systems engineering domain to truly bridge scientific curiosity with real-world applications applied to biomanufacturing. We continue our efforts to demonstrate near term industrial applications of quantum computing and Agentic AI to bring them to the manufacturing floor”.

— said Prof. Seyed Soheil Mansouri, Founder at SiC Systems and Associate Professor at the Technical University of Denmark

SiC Systems was founded by Christopher J. Savoie–whose pioneering work with AI agents led to the assistants we know today in mobile devices, smart speakers and beyond–and Seyed Soheil Monsouri, Professor of Process Systems Engineering at the Technical University of Denmark (DTU), a pioneer of applying model-based tools to complex multi-scale dynamic systems including quantum computing to (bio and chemical) manufacturing applications. Prof Mansouri is the anchor author on the recent study leading to this award.

The company last month launched with a funding round led by QDNL Participations, with participation from Propagator Ventures, Plug and Play, and Wavepeak Ventures.

SiC Systems is now exploring use cases for its technology to enhance a range of complex industrial processes.

The results of the research were released publicly last month and can be accessed here in the paper Quantum enhanced ensemble GANs for anomaly detection in continuous biomanufacturing, by Rajiv Kailasanathan, William R Clements, Mohammad Reza Boskabadi, Shawn M. Gibford, Emmanouil Papadakis, Christopher J. Savoie and Seyed Soheil Mansouri.

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MENTIONED IN THE ARTICLE

ORCA Computing
CompanyUnited Kingdom · 51-100 FTEs

Orca Computing is developing a modular quantum computing platform using photonic technology.

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DTU
UniversityDenmark · 5001-10000 FTEs

The Technical University of Denmark (DTU) is a leading polytechnic university with a strong focus on research and innovation3. The Department of Electrical and Photonics Engineering, also known as DTU Electro, is a world-leading institution within the university. DTU Electro employs over 220 researchers and is at the forefront of optical communications, networks, and photonic integration36. The department combines the possibilities of electrical and photonics engineering to drive innovation in various field

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NVIDIA
InvestorUnited States · 10001+ FTEs

NVIDIA Corporation is an American multinational technology company and a global player in accelerated computing and Artificial Intelligence (AI). Founded in 1993, the company pushes the aerospace frontier with the Space-1 Vera Rubin Module, a platform for orbital data centers that delivers massive AI-compute Space Computing. This NVIDIA technology enables satellites and autonomous spacecraft to process and fuse sensor data rapidly Space Computing.

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NASA
InvestorUnited States · 10001+ FTEs

The National Aeronautics and Space Administration (NASA) is the U.S. government agency driving pioneering research and technological development in both atmospheric flight (aeronautics) and space exploration (astronautics). NASA acts as a research organization, utilizing advanced wind tunnels, supercomputing, and flight test laboratories to advance aircraft aerodynamics, propulsion, and materials, while simultaneously involved in the design, construction, and operation of launch vehicles and spacecraft for deep space exploration. Through its aeronautics research directorate, the agency works to improve the safety, efficiency, and environmental impact of aviation, whereas its space programs focus on developing cutting-edge flight systems, robotic explorers, and human transportation capabilities.

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Microsoft
InvestorUnited States · 10001+ FTEs

Microsoft engages in the creation and licensing of software for both consumer and enterprise use. The company is renowned for its development of Windows operating systems and the Office suite designed for productivity. Microsoft's structure encompasses three major segments of roughly equal size: productivity and business processes, which encompasses legacy Microsoft Office, cloud-based Office 365, Exchange, SharePoint, Skype, LinkedIn, and Dynamics; the intelligence cloud, which includes offerings like Azure, Windows Server OS, and SQL Server; and more personal computing, which covers Windows Client, Xbox, Bing search, display advertising, and a range of Surface laptops, tablets, and desktops.

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Quantinuum
CompanyUnited Kingdom · 101-500 FTEs

Quantinuum is a quantum computing company advancing the aerospace sector through the development of algorithms for aerodynamic modeling, composite materials optimization, and sustainable aviation fuel cell engineering. Founded in 2021 through the merger of Cambridge Quantum and Honeywell Quantum Solutions, the firm provides high fidelity trapped ion hardware and software to accelerate industrial applications.

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