Main Sequence Promotes Alejandra Romero to Principal

Insider Brief

• Main Sequence Ventures has promoted Alejandra Romero to Principal, reinforcing its investment focus on advanced computing hardware, semiconductors, quantum technologies and AI infrastructure.
• Since joining the firm in 2023, Romero has led investments in companies including Q-CTRL, Diraq and Quantum Brilliance, co-authored Main Sequence’s Quantum Investment Thesis, and helped build and scale deep-tech startups through its Venture Science model.
• Romero said future computing leadership will depend on control of hardware and physical infrastructure, arguing that advances in semiconductors, quantum systems and AI hardware will create competitive advantage by translating complex physics into commercially deployable technologies.

PRESS RELEASE — Main Sequence Ventures, Australia’s deep tech venture capital firm, has promoted Alejandra Romero (Alex) to Principal — doubling down on its bet that the next wave of computing gets won at the hardware layer, not just in software.

Romero leads Main Sequence’s investments across advanced physical systems, semiconductors, quantum and AI hardware. She co-authored the firm’s Quantum Investment Thesis, has backed pioneers like Q-CTRL, Diraq and Quantum Brilliance, and has built new companies from the ground up.

“My proudest work so far has been building Cortisonic through our Venture Science model,” said Romero. 

“We took foundational university technology to market with Lockheed Martin as our first commercial partner. That partnership is now shaping how we expand the strategic model into other commercial domains. Helping companies fundraise through significant, large-scale rounds and expand successfully overseas has also been a defining part of that journey.”

Romero believes that the sector’s narrative must expand past the promise of future computing to the immediate reality of physical substrate. 

“The next era of computing isn’t defined by any one paradigm — quantum, semiconductors, AI hardware — it’s defined by who controls the physics advantage and the infrastructure built around it,” she said. 

“True advantage happens at the hardware level. Whether it’s new semiconductor architectures, AI chips or sensing systems, our job is to translate complex physics into tangible infrastructure that regular markets can easily value and adopt.”

Since joining Main Sequence in 2023, Romero has progressed from Investment Analyst to Principal, working closely with CSIRO, universities and research institutions. Her early career and path into venture spans science, marketing and sales roles across Europe, plus co-founding a cross-border humanitarian nonprofit. She previously commercialised university research at Uniseed and holds honours degrees in applied science from Universitat Autònoma de Barcelona and Universidad Complutense de Madrid.